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Article

RNA leaching of transcription factors disrupts transcription in myotonic dystrophy.

Science (New York, N.Y.) - 16 Jan 2004

Ebralidze A, Wang Y, Petkova V, Ebralidse K, Junghans R P

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is caused by a CUGn expansion (n approximately 50 to 5000) in the 3' untranslated region of the mRNA of the DM protein kinase gene. We show that mutant RNA binds and sequesters transcription factors (TFs), with up to 90% depletion of selected TFs from active chromatin. Diverse genes are consequently reduced in expression, including the ion transporter CIC-1, which has been...

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Identifiers

PMID: 14657503
DOI: 10.1126/science.1088679

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CIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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