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Article

Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis.

The Journal of biological chemistry - 26 Mar 2004

Timchenko Nikolai A, Patel Roma, Iakova Polina, Cai Zong-Jin, Quan Ling, Timchenko Lubov T

Abstract excerpt

Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the induction of a CUG-binding protein, CUGBP1, which increases translation of several proteins that are required for myogenesis. In this paper, we examine the role of overexpression of CUGBP1 in DM1 muscle pathology using transgenic mice that overexpress CUGBP1 in skeletal muscle. Our data demonstrate that the elevation of...

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PMID: 14722059
DOI: 10.1074/jbc.M312923200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis.PMID 14722059Read ↗

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