Article
High capacity substrates as a platform for a DNA probe array genotyping assay.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2000
Fidanza J, Glazer M, Mutnick D, McGall G, Frank C
Abstract excerpt
Colloidal silica particles were deposited on a glass substrate to produce high-capacity porous supports for high-density DNA probe arrays. Porous surfaces were used to increase the addressable surface area and number of probes available for hybridization. Surfaces derived from 70-100 nm size particles deposited in films from 0.15 to 2 microns thick exhibited excellent performance in light-directed oligonucleotide...
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