Article
Occult micrometastasis: enrichment, identification and characterization of single disseminated tumour cells.
Seminars in cancer biology - 1 Oct 2001
Pantel K, Otte M
Abstract excerpt
The decision as to whether systemic adjuvant therapy should be applied in breast cancer patients for secondary prevention of metastatic relapse is based solely on the statistical prognosis. For this reason, the direct identification of minimal residual cancer in distant organs (e.g. bone marrow) is of particular importance. In breast cancer 25-43% of the patients exhibit micrometastatic disease in bone marrow,...
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