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Article

Detection of micrometastatic disease in bone marrow: is it ready for prime time?

The oncologist - 1 Aug 2005

Janni Wolfgang, Rack Brigitte, Lindemann Kristina, Harbeck Nadia

Abstract excerpt

Minimal residual disease (MRD), or isolated tumor cells (ITCs) in bone marrow, may be the source of potentially fatal overt distant metastases in solid tumors even years after primary treatment. MRD can be detected by immunohistochemical methods using antibodies directed against cytokeratins or cell-surface markers or molecular, polymerase chain reaction-based techniques. Among solid tumors, the clinical...

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PMID: 16079315
DOI: 10.1634/theoncologist.10-7-480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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