Article
Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.
Genetics - 1 Sept 2001
Tsutsui Y, Khasanov F K, Shinagawa H, Iwasaki H, Bashkirov V I
Abstract excerpt
Schizosaccharomyces pombe Rhp55 and Rhp57 are RecA-like proteins involved in double-strand break (DSB) repair. Here we demonstrate that Rhp55 and Rhp57 proteins strongly interact in vivo, similar to Saccharomyces cerevisiae Rad55p and Rad57p. Mutations in the conserved ATP-binding/hydrolysis folds of both the Rhp55 and Rhp57 proteins impaired their function in DNA repair but not in cell proliferation. However,...
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