Article
Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.
Genetics - 1 Sept 2001
Tsutsui Y, Khasanov F K, Shinagawa H, Iwasaki H, Bashkirov V I
Abstract excerpt
Schizosaccharomyces pombe Rhp55 and Rhp57 are RecA-like proteins involved in double-strand break (DSB) repair. Here we demonstrate that Rhp55 and Rhp57 proteins strongly interact in vivo, similar to Saccharomyces cerevisiae Rad55p and Rad57p. Mutations in the conserved ATP-binding/hydrolysis folds of both the Rhp55 and Rhp57 proteins impaired their function in DNA repair but not in cell proliferation. However,...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Alleles
- Animals
- Chromosomes
- DNA
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Dimerization
- Evolution, Molecular
- Fungal Proteins
- Gene Deletion
- Hydrolysis