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Article

Regeneration of Hyaline Cartilage by Cell-Mediated Gene Therapy Using Transforming Growth Factor β 1-Producing Fibroblasts

20 Sept 2001

Abstract excerpt

Transforming growth factor beta (TGF-beta) has been considered as a candidate for gene therapy of orthopedic diseases. The possible application of cell-mediated TGF-beta gene therapy as a new treatment regimen for degenerative arthritis was investigated. In this study, fibroblasts expressing active TGF-beta 1 were injected into the knee joints of rabbits with artificially made cartilage defects to evaluate the...

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PMID: 11560773
DOI: 10.1089/104303401750476294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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