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Article

Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2001

Mackness B, Davies G K, Turkie W, Lee E, Roberts D H, Hill E, Roberts C, Durrington P N, Mackness M I

Abstract excerpt

Human serum paraoxonase (PON1) hydrolyzes oxidized lipids in low density lipoprotein (LDL) and could therefore retard the development of atherosclerosis. In keeping with this hypothesis, several case-control studies have shown a relationship between the presence of coronary heart disease (CHD) and polymorphisms at amino acid positions 55 and 192 of PON1, which we associated with a decreased capacity of PON1 to...

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Source

Identifiers

PMID: 11557671
DOI: 10.1161/hq0901.094247

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?PMID 11557671Read ↗

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Quantitative Assessment of the Influence of Paraoxonase 1 Activity and Coronary Heart Disease RiskSemantic proximity Read ↗

A preliminary study of human paraoxonase and PON 1 L/M55-PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease.Semantic proximity Read ↗

Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

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