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Article

Selective Deposition of Mutant Tau in the FTDP-17 Brain Affected by the P301L Mutation

1 Sept 2001

Abstract excerpt

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a familial neurological disorder exhibiting autosomal dominant inheritance. Linkage analyses have led to the identification of many exonic and intronic mutations in the tau gene in affected families. Because FTDP- 17 causes extensive neuronal loss and intracellular tau deposits in affected regions, investigation of this disease should...

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PMID: 11556544
DOI: 10.1093/jnen/60.9.872

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Related research

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Selective Deposition of Mutant Tau in the FTDP-17 Brain Affected by the P301L MutationPMID 11556544Read ↗

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