Article
Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.
The American journal of pathology - 1 Feb 2001
Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten J C, Nagashima K, Ihara Y
Abstract excerpt
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a familial neurological disorder, characterized genetically by autosomal dominant inheritance, clinically by behavioral abnormalities and parkinsonism, and neuropathologically by tauopathy. Linkage analyses of affected families have led to identification of several exonic and intronic mutations in the tau gene. In this study, we...
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