The origin of the major cystic fibrosis mutation (delta F508) in European populations.

doi:10.1038/ng0694-169

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Article

The origin of the major cystic fibrosis mutation (delta F508) in European populations.

Nature genetics - 1 Jun 1994

Morral N, Bertranpetit J, Estivill X, Nunes V, Casals T, Giménez J, Reis A, Varon-Mateeva R, Macek M, Kalaydjieva L

Abstract excerpt

delta F508 is the most frequent cystic fibrosis (CF) mutation and accounts for approximately 70% of CF chromosomes worldwide. Three highly polymorphic microsatellite markers have been used to study the origin and evolution of delta F508 chromosomes in Europe. Haplotype data demonstrate that delta...

Topics

Biological Evolution
Cystic Fibrosis
Europe
Genetic Markers
Genetic Variation
Genetics, Population
Haplotypes
Humans
Mutation
Repetitive Sequences, Nucleic Acid
Time Factors

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