Article
Segregation of effector mechanisms in a tumour-specific CD8+ T-cell clone correlates with CD30 expression.
Scandinavian journal of immunology - 1 Sept 2001
Sun Y, Song M, Maeurer M J, Schadendorf D
Abstract excerpt
In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-gamma). We show that all CTL clones expressed high levels of CD30 upon contact with the autologous tumour cells. One CTL clone, termed A2 with a monoclonal feature was selected for further...
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