Segregation of effector mechanisms in a tumour-specific CD8+ T-cell clone correlates with CD30 expression.

doi:10.1046/j.1365-3083.2001.00971.x

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Article

Segregation of effector mechanisms in a tumour-specific CD8+ T-cell clone correlates with CD30 expression.

Scandinavian journal of immunology - 1 Sept 2001

Sun Y, Song M, Maeurer M J, Schadendorf D

Abstract excerpt

In this study we have analyzed CD30-antigen expression in three melanoma-directed cytotoxic T lymphocyte (CTL) clones with a T helper 0 (Th0)-like cytokine secretion profile (i.e. interleukin (IL)-4, IL-5, and interferon (IFN)-gamma). We show that all CTL clones expressed high levels of CD30 upon contact with the autologous tumour cells. One CTL clone, termed A2 with a monoclonal feature was selected for further...

Topics

Cell Line, Transformed
Clone Cells
Cytokines
Cytotoxicity Tests, Immunologic
Humans
Interferon-gamma
Interleukin-4
K562 Cells
Ki-1 Antigen
Lymphocyte Activation
Melanoma
Phenotype
T-Lymphocytes, Cytotoxic
Tumor Cells, Cultured

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Open in PubMed

Identifiers

PMID: 11555396
DOI: 10.1046/j.1365-3083.2001.00971.x

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