Article
IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia.
British journal of haematology - 1 Mar 1999
de Totero D, Reato G, Mauro F, Cignetti A, Ferrini S, Guarini A, Gobbi M, Grossi C E, Foa R
Abstract excerpt
Phenotypic and functional abnormalities within the residual non-B-cell compartment of B-cell chronic lymphocytic leukaemia (CLL) suggest an interaction between tumour cells and host immune effectors. To explore the possibility of a polarized Th1/Th2 response we have studied CD30 antigen expression and the pattern of cytokine production by purified CLL T cells. Activated T cells from CLL patients showed a...
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