Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo.

Microbiology (Reading, England) - 1 Sept 2001

Mukherjee Pranab K, Seshan K R, Leidich S D, Chandra Jyotsna, Cole Garry T, Ghannoum Mahmoud A

Abstract excerpt

Phospholipases have been proposed to contribute to the virulence of Candida albicans. Recently, a candidal strain deleted for PLB1, the gene encoding the predominant phospholipase B (Plb1) secreted by C. albicans, was constructed and its virulence in an intravenous murine model of disseminated candidiasis was evaluated. In the present study, the PLB1 gene was reintroduced back into the plb1 null mutant to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Candidiasis
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gastric Mucosa

Share to Genes, Fungal

Share to Microscopy, Electron

Share to Virulence

Source

Identifiers

PMID: 11535799
DOI: 10.1099/00221287-147-9-2585

Genes

PLB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo.PMID 11535799Read ↗

Potential Role of Phospholipases in Virulence and Fungal PathogenesisSemantic proximity Read ↗

Potential Role of Phospholipases in Virulence and Fungal PathogenesisSemantic proximity Read ↗

Candida glabrata intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscesses.Semantic proximity Read ↗

Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicansSemantic proximity Read ↗

Candida albicans PLD I activity is required for full virulence.Semantic proximity Read ↗

Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence.Semantic proximity Read ↗

Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.Semantic proximity Read ↗

Differential<i>Candida albicans</i>lipase gene expression during alimentary tract colonization and infectionSemantic proximity Read ↗

The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicans.Semantic proximity Read ↗

Virulence attenuation of Candida albicans genetic variants isolated from a patient with a recurrent bloodstream infection.Semantic proximity Read ↗

Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine.Semantic proximity Read ↗

Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.