Article
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.
Molecular microbiology - 1 Jan 2001
Cox G M, McDade H C, Chen S C, Tucker S C, Gottfredsson M, Wright L C, Sorrell T C, Leidich S D, Casadevall A, Ghannoum M A, Perfect J R
Abstract excerpt
The human pathogenic fungus Cryptococcus neoformans secretes a phospholipase enzyme that demonstrates phospholipase B (PLB), lysophospholipase hydrolase and lysophospholipase transacylase activities. This enzyme has been postulated to be a cryptococcal virulence factor. We cloned a phospholipase-encoding gene (PLB1) from C. neoformans and constructed plb1 mutants using targeted gene disruption. All three enzyme...
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