Article
Alterations in kidney morphology in mice with mosaic mutation.
Folia histochemica et cytobiologica - 1 Jan 2001
Lenartowicz M, Sasuła K, Zawadowska B
Abstract excerpt
The mosaic (Atp7a(mo-ms)) is an X-linked, lethal mutation in mice. Hemizygous males die at the age of 15 days and they exhibit strong similarities to the brindled and macular mutants. Injection of cupric chloride to mossaic mutants prolongs their life and diminishes the pathological results of mutation. Histochemical analysis of the kidneys from 14-day-old mutant males showed accumulation of copper in the renal...
Topics
- Animals
- Copper
- Female
- Histocytochemistry
- Humans
- Kidney
- Male
- Menkes Kinky Hair Syndrome
- Mice
- Mice, Mutant Strains
- Mutation
- Organ Size
- Statistics as Topic