Article
Testicular morphology and expression of aromatase in testes of mice with the mosaic mutation (Atp7a mo-ms).
Theriogenology - 15 Jan 2007
Kotula-Balak Małgorzata, Lenartowicz Małgorzata, Kowal Małgorzata, Styrna Józefa, Bilińska Barbara
Abstract excerpt
The aim of this study was to determine whether testicular cells of mice with the mosaic mutation, associated with abnormal copper metabolism, are able to aromatize androgens to estrogens, and what is the putative role of estrogens in the gonad of the mutant male. Mosaic is a lethal mutation; affected males usually die on about day 16. Those, which survive to reach sexual maturity, are valuable research subjects....
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