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Article

HTLV-1 intragenic viral enhancer influences immortalization phenotype in vitro, but is dispensable for persistence and disease development in animal models.

Frontiers in immunology - 1 Jan 2022

Maksimova Victoria, Smith Susan, Seth Jaideep, Phelps Cameron, Niewiesk Stefan, Satou Yorifumi, Green Patrick L, Panfil Amanda R

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) is the causative infectious agent of adult T-cell leukemia/lymphoma (ATL) and chronic neurological disease. The disparity between silenced sense transcription versus constitutively active antisense (Hbz) transcription from the integrated provirus is not fully understood. The presence of an internal viral enhancer has recently been discovered in the Tax gene near the 3'...

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Identifiers

PMID: 35958554
DOI: 10.3389/fimmu.2022.954077
PMCID: PMC9359075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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