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Article

Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.

Journal of clinical microbiology - 1 Nov 2014

Deng Xilong, Zhuo Li, Lan Yun, Dai Zhaoxia, Chen Wan-shan, Cai Weiping, Kovacs Joseph A, Ma Liang, Tang Xiaoping

Abstract excerpt

We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.

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Source

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Identifiers

PMID: 25122865
DOI: 10.1128/JCM.01848-14
PMCID: PMC4313241

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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