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Article

Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression

5 Feb 2014

Abstract excerpt

Hippo-like MST1 protein kinase regulates cell growth, organ size, and carcinogenesis. Reduction or loss of MST1 expression is implicated in poor cancer prognosis. However, the mechanism leading to MST1 silencing remains elusive. Here, we report that both MYC and EZH2 function as potent suppressors of MST1 expression in human prostate cancer cells. We demonstrated that concurrent overexpression of MYC and EZH2...

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PMID: 24499724
DOI: 10.4161/epi.27957

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