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Article

Elevated function of blood clotting factor VIIa mutants that have enhanced affinity for membranes. Behavior in a diffusion-limited reaction.

The Journal of biological chemistry - 26 Oct 2001

Nelsestuen G L, Stone M, Martinez M B, Harvey S B, Foster D, Kisiel W

Abstract excerpt

Blood clotting factor VIIa is involved in the first step of the blood coagulation cascade, as a membrane-associated enzyme in complex with tissue factor (TF). Factor VIIa is also an important therapeutic agent for hemophilia where its function may include TF-independent as well as TF-dependent mechanisms. This study compared the activity of wild type factor VIIa (WT-VIIa) with that of a mutant with elevated...

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Identifiers

PMID: 11517221
DOI: 10.1074/jbc.M104896200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated function of blood clotting factor VIIa mutants that have enhanced affinity for membranes. Behavior in a diffusion-limited reaction.PMID 11517221Read ↗

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Variants of recombinant factor VIIa with increased intrinsic activity.Semantic proximity Read ↗

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.Semantic proximity Read ↗

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