Article
Evaluation of an antibody-based genotype classification of the platelet fibrinogen receptor (GPIIb/IIIa).
Cytometry - 15 Aug 2001
Schwippert-Houtermans B, Strapatsakis S, Roesen P, Tschoepe D
Abstract excerpt
Platelet membrane glycoprotein (GP) IIb/IIIa is the central molecule in platelet adhesion and aggregation by high-affinity binding of fibrinogen. Polymorphism of the beta chain of the receptor, especially the GPIIIa-proline33 allele [HPA-1b, Zwb, PI(A2)], has been suggested to be associated with a variety of vascular diseases, such as coronary stenosis, myocardial infarction, cerebral ischemia, or venous...
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