Article
FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2004
Cunningham Melissa A, Zhu Qin, Hammond James M
Abstract excerpt
Forkhead transcription factors of the FOXO family are important downstream targets of the phosphatidylinositol 3-kinase pathway, which has been shown to play a critical role in cell proliferation and cell survival. Activation of FOXOs can block cellular proliferation and drive cells into a quiescent state. In certain cell types, this cell cycle arrest is dependent on the transcriptional induction of the...
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