Article
Increased incidence of sporadic Creutzfeldt-Jakob disease on the island of Crete associated with a high rate of PRNP 129-methionine homozygosity in the local population.
Annals of neurology - 1 Aug 2001
Plaitakis A, Viskadouraki A K, Tzagournissakis M, Zaganas I, Verghese-Nikolakaki S, Karagiorgis V, Panagiotides I, Kilindireas C, Patsouris E, Haberler C, Budka H, Sklaviadis T
Abstract excerpt
Since the spring of 1997, when the Neurology Department of the University Hospital of Crete admitted its first patient, nine cases (eight neuropathologically confirmed and one probable) of sporadic Creutzfeldt-Jakob disease (sCJD) have been recorded. This represents an annual incidence five-fold higher than expected based on the island's population (0.54 million). Molecular analysis of the prion-protein gene...
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