Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 1999

Raffel C, Frederick L, O'Fallon J R, Atherton-Skaff P, Perry A, Jenkins R B, James C D

Abstract excerpt

Although common among adult intracranial neoplasms, pediatric malignant astrocytomas (PMAs) comprise a relatively small proportion of the brain tumors that occur in children. The scarcity of such cases generally requires that molecular analyses of PMAs are based on the utilization of paraffin-embedded material, and here we have used 39 such specimens to examine the incidence and prognostic significance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Oncogenes

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Survival Analysis

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 10632344

Genes

PTEN
EGFR
CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.PMID 10632344Read ↗

Molecular pathogenesis of pediatric astrocytic tumors.Semantic proximity Read ↗

p53 protein in pediatric malignant astrocytomas: a study of 21 patients.Semantic proximity Read ↗

Genetic alterations in pediatric high-grade astrocytomas.Semantic proximity Read ↗

Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort.Semantic proximity Read ↗

PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma MultiformeSemantic proximity Read ↗

Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.Semantic proximity Read ↗

Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation.Semantic proximity Read ↗

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.Semantic proximity Read ↗

Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood.Semantic proximity Read ↗

Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas.Semantic proximity Read ↗

Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.Semantic proximity Read ↗

Cooperative interactions of BRAF <sup>V600E</sup> kinase and <i>CDKN2A</i> locus deficiency in pediatric malignant astrocytoma as a basis for rational therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.