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Article

Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.

Neurology - 14 Aug 2001

Graf W D, Unis A S, Yates C M, Sulzbacher S, Dinulos M B, Jack R M, Dugaw K A, Paddock M N, Parson W W

Abstract excerpt

OBJECTIVE: To investigate catecholamine phenotypes and the effects of a tyrosine hydroxylase inhibitor in individuals with the 22q11.2 deletion syndrome and low-activity catechol-O-methyltransferase (COMT). BACKGROUND: Many persons with the 22q11.2 deletion syndrome suffer severe disability from a characteristic ultrarapid-cycling bipolar disorder and associated "affective storms." One etiologic hypothesis for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 22

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Source

Identifiers

PMID: 11502905
DOI: 10.1212/wnl.57.3.410

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.PMID 11502905Read ↗

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