Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.

Journal of medicinal chemistry - 18 Jun 1998

Fan Y, Weinstein J N, Kohn K W, Shi L M, Pommier Y

Abstract excerpt

The present studies provide a three-dimensional model for the postulated ternary cleavable complex of topoisomerase I (top1), DNA, and camptothecin (CPT). Molecular simulations were done using the AMBER force field. The results suggest that a ternary cleavable complex might be stabilized by several hydrogen bonds in the binding site. In this proposed "drug-stacking" model, CPT is pseudointercalated in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Antineoplastic Agents
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Protein Conformation

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 9632354
DOI: 10.1021/jm9605445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.PMID 9632354Read ↗

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin.Semantic proximity Read ↗

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.Semantic proximity Read ↗

Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA ComplexSemantic proximity Read ↗

Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations.Semantic proximity Read ↗

The mechanism of topoisomerase I poisoning by a camptothecin analog.Semantic proximity Read ↗

The Current Status of Camptothecin Analogues as Antitumor AgentsSemantic proximity Read ↗

Novel camptothecin derivatives as topoisomerase I inhibitorsSemantic proximity Read ↗

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.Semantic proximity Read ↗

Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.Semantic proximity Read ↗

Recent developments in topoisomerase-targeted cancer chemotherapySemantic proximity Read ↗

The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damageSemantic proximity Read ↗

Cryo-EM structural analysis of human TOP1 trapping by eight clinical anticancer drugsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.