Article
Rapid mutation scanning of genes associated with familial cancer syndromes using denaturing high-performance liquid chromatography.
Neoplasia (New York, N.Y.) - 1 Jan 2001
Marsh D J, Theodosopoulos G, Howell V, Richardson A L, Benn D E, Proos A L, Eng C, Robinson B G
Abstract excerpt
Germline mutations in tumor suppressor genes, or less frequently oncogenes, have been identified in up to 19 familial cancer syndromes including Li-Fraumeni syndrome, familial paraganglioma, familial adenomatous polyposis coli and breast and ovarian cancers. Multiple genes have been associated with some syndromes as approximately 26 genes have been linked to the development of these familial cancers. With this...
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