Article
Validation of denaturing high performance liquid chromatography as a rapid detection method for the identification of human INK4A gene mutations.
The Journal of molecular diagnostics : JMD - 1 Nov 2001
Orlow I, Roy P, Barz A, Canchola R, Song Y, Berwick M
Abstract excerpt
The incidence of melanoma is increasing rapidly in western countries. Genetic predisposition in familial and in some sporadic melanomas has been associated with the presence of INK4A gene mutations. To better define the risk for developing sporadic melanoma based on genetic and environmental interactions, large groups of cases need to be studied. Mutational analysis of genes lacking hot spots for sequence...
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