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Article

Denaturing gradient gel electrophoresis to diagnose multiple endocrine neoplasia type 2.

Clinical chemistry - 1 Apr 1996

Blank R D, Sklar C A, Martin M L

Abstract excerpt

Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant cancer syndrome caused by mutations in the RET protooncogene. Others have already demonstrated the value of genetic testing in known MEN 2 kindreds. Previously described approaches to DNA-level diagnosis, particularly of index cases, are tedious. We developed appropriate denaturing gradient gel electrophoresis (DGGE) conditions for analysis of...

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PMID: 8605678

Genes

RET

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