Article
Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator.
Histopathology - 1 Aug 2001
Watanabe T, Oda Y, Tamiya S, Kinukawa N, Masuda K, Tsuneyoshi M
Abstract excerpt
AIMS: We investigated p53, Ki67, MDM2, and p21WAF1/CIP1 in order to evaluate its relationship with prognosis in malignant peripheral nerve sheath tumours (MPNST). METHODS AND RESULTS: In 49 cases of MPNSTs, the immunohistochemical studies of Ki67, p53, MDM2, p21WAF1/CIP1 and polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) with direct sequencing of p53 were performed with the...
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