Article
Human leukocyte antigen gene polymorphism and the histocompatibility laboratory.
The Journal of molecular diagnostics : JMD - 1 Aug 2001
Williams T M
Abstract excerpt
The human leukocyte antigens (HLA) encoded by genes within the major histocompatibility complex display an impressive degree of polymorphism. This variability is apparently maintained in human populations through the need to successfully display a wide range of processed foreign peptides to the T cell antigen receptor. The large number of alleles at the Class I and Class II loci pose a significant problem for...
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