Article
Molecular genetics of the HLA complex.
Wiener klinische Wochenschrift - 30 Oct 2001
Fischer G F, Mayr W R
Abstract excerpt
The Human Leukocyte Antigen (HLA) system can be defined as a set of glycoproteins which take up peptides intracellulary and become ligands for immune receptors once they are expressed on the cell membrane. Functional HLA molecules are trimers consisting of a heavy chain and a light chain which bind a peptide. The production of HLA molecules in the endoplasmic reticulum, their assembly and their trafficking to the...
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