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Article

Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3.

Cancer letters - 28 Sept 2001

Clarke K O, Feinman R, Harrison L E

Abstract excerpt

The purpose of this study was to investigate the anti-proliferative and pro-apoptotic effects of the butyrate analogues, tributyrin (TB) and phenylbutyrate (PB), in a colon cancer model. We demonstrate that HT-29 colon cancer cells exposed to PB and TB result in growth inhibition associated with an induction of apoptosis mediated through the activation of caspase-3 activity. A block in the G1/S cell cycle...

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Source

Identifiers

PMID: 11485828
DOI: 10.1016/s0304-3835(01)00574-2

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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