Article
Functional abnormalities in protein tyrosine phosphatase epsilon-deficient macrophages.
Biochemical and biophysical research communications - 10 Aug 2001
Sully V, Pownall S, Vincan E, Bassal S, Borowski A H, Hart P H, Rockman S P, Phillips W A
Abstract excerpt
Protein tyrosine phosphatase epsilon (PTP epsilon)-deficient mice were generated by targeted deletion of exons 3, 4, and 5 of the Ptpre gene. Mice homozygous for this deletion (Ptpre(Delta3-5)) were fertile, bred and developed normally and exhibited no overt phenotype. However, closer examination of the function of macrophages from these mice revealed a defect in the regulation of the respiratory burst. While...
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