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Alphavirus vectors for vaccine production and gene therapy

1 Jun 2003

Abstract excerpt

Alphavirus vectors demonstrate high expression of heterologous proteins in a broad range of host cells. Replication-deficient as well as replication-competent variants exist. Systemic delivery of many viral antigens has elicited strong antibody responses in immunized mice and primates, and protection against challenges with lethal viruses was obtained. Similarly, prophylactic vaccination was established against...

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PMID: 12903809
DOI: 10.1586/14760584.2.3.445

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