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Article

Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.

Neuroscience - 1 Jan 2001

Ravizza T, Moneta D, Bottazzi B, Peri G, Garlanda C, Hirsch E, Richards G J, Mantovani A, Vezzani A

Abstract excerpt

Pentraxin 3, a prototypic long pentraxin, is induced by proinflammatory signals in the brain. Inflammatory cytokines are rapidly induced in glia by epileptic activity. We show that pentraxin 3 immunoreactivity and mRNA are enhanced in the rat forebrain above undetectable control levels by limbic seizures with a dual pattern of induction. Within 6 h from seizure onset, pentraxin 3 immunoreactivity was increased in...

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Source

Identifiers

PMID: 11483299
DOI: 10.1016/s0306-4522(01)00177-4

Genes

PTX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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