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REPARIXIN AS A POTENTIAL ANTI-EPILEPTOGENIC AGENT: MODULATION OF CXCL1-CXCR1/2 AXIS AND SEIZURE ACTIVITY IN KINDLING MODEL OF TEMPORAL LOBE EPILEPSY

2025-02-10

Abstract excerpt

Chemokine (CXC motif) ligand 8 (CXCL8) is a pro-inflammatory chemokine binding to CXCR1/2 receptors, is elevated in the serum of patients with Temporal Lobe Epilepsy (TLE). Its murine ortholog CXCL1, is implicated in seizure generation and neuronal loss. This study evaluates the anti-epileptogenic and anti-seizure effect of reparixin, an allosteric CXCR1/2 antagonist in amygdaloid kindling rat model of TLE. Repari...

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Literature Corpus work
8e99c516-f917-5565-a52b-cac174a1e850
DOI
10.20944/preprints202502.0583.v1
Open publication

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REPARIXIN AS A POTENTIAL ANTI-EPILEPTOGENIC AGENT: MODULATION OF CXCL1-CXCR1/2 AXIS AND SEIZURE ACTIVITY IN KINDLING MODEL OF TEMPORAL LOBE EPILEPSYDOI 10.20944/preprints202502.0583.v1
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