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THE METHYLENE TETRAHYDROFOLATE REDUCTASE (C677T) MUTATION AS A POTENTIAL RISK FACTOR FOR AVASCULAR NECROSIS IN SICKLE CELL DISEASE

1 Jan 2001

Abstract excerpt

Avascular necrosis (AVN) of the humeral and femoral heads is a frequent and debilitating complication of sickle cell disease. Some of the risk factors for AVN are alpha-thalassemia and age. Recently, newly discovered thrombophilia mutations have been associated with AVN in patients without sickle cell disease. We studied the frequency of the thermolabile methylene tetrahydrofolate reductase (MTHFR) variant...

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PMID: 11480782
DOI: 10.1081/hem-100104029

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