Article
Prothrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahydrofolate reductase among patients with sickle cell disease in Brazil.
American journal of hematology - 1 Sept 1998
Andrade F L, Annichino-Bizzacchi J M, Saad S T, Costa F F, Arruda V R
Abstract excerpt
The prevalence of the prothrombin gene variant (allele 20.210 A), factor V Leiden mutation, and homozygosity for transition 677C-->T in the methylenetetrahydrofolate reductase (MTHFR) gene was determined among patients with sickle cell disease (SCD). The group included 73 patients with median age...
Topics
- Adolescent
- Adult
- Anemia, Sickle Cell
- Brazil
- Factor V
- Female
- Gene Frequency
- Genetic Variation
- Heterozygote
- Homozygote
- Humans
- Leg Ulcer
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Osteonecrosis
- Oxidoreductases Acting on CH-NH Group Donors