Article
Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease.
American journal of hematology - 1 Dec 1998
Zimmerman S A, Ware R E
Abstract excerpt
Thrombosis may play an important role in the pathophysiology of certain complications of sickle cell disease (SCD), including stroke and avascular necrosis (AVN). Currently there is no laboratory or clinical parameter that can identify patients who are at highest risk of developing these thrombot...
Topics
- Adolescent
- Adult
- Amino Acid Substitution
- Anemia, Sickle Cell
- Cerebrovascular Disorders
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Femur Head Necrosis
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Humerus
- Ischemia
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)