Article
Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 1999
Kieper W C, Jameson S C
Abstract excerpt
Recent data suggest that survival of resting, naïve T cells requires an interaction with self MHC molecules. From analysis of the class I MHC-restricted T cell receptor transgenic strain OT-I, we report a different response. Rather than merely surviving, these T cells proliferated slowly after transfer into T-depleted syngeneic hosts. This expansion required both T cell "space" and expression of normal levels of...
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