Article
Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India.
Indian journal of pathology & microbiology - 1 Jan 2000
Rana Ranjan S, Naik Bitan, Yadav Mahima, Singh Usha, Singh Anup, Singh Shailja
Abstract excerpt
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder and has complex etiopathogenesis. The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. HLA class II alleles are critical to immune response and are highly polymorphic. Various alleles in HLA-DR and -DQ regions were analyzed in SLE patients and healthy...
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