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Article

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.

Experimental neurology - 1 Aug 2001

Jaffar S, Counts S E, Ma S Y, Dadko E, Gordon M N, Morgan D, Mufson E J

Abstract excerpt

Cholinergic basal forebrain (CBF) projection systems are defective in late Alzheimer's disease (AD). We examined the brains of 12-month-old singly and doubly transgenic mice overexpressing mutant amyloid precursor protein (APP(swe)) and/or presenilin-1 (PS1(M146L)) to investigate the effects of these AD-related genes on plaque and tangle pathology, astrocytic expression, and the CBF projection system. Two types...

Topics

Alzheimer Disease
Amino Acid Substitution
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Brain
Cerebral Cortex
Hippocampus
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Mice, Transgenic

Mutation

Nerve Fibers

Neurites

Neurons

Plaque, Amyloid

Source

Identifiers

PMID: 11476589
DOI: 10.1006/exnr.2001.7710

Genes

APP
NGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11476589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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