Article
DNA amplification associated with double minutes originating from chromosome 19 in mouse hepatocellular carcinoma.
Cytogenetics and cell genetics - 1 Jan 2001
Zimonjic D B, Zhang H, Shan Z, Factor V, Trent J, Thorgeirsson S S, Popescu N C
Abstract excerpt
DNA amplification is associated with genomic instability, the main characteristic of cancer cells, and it frequently involves protooncogenes. Double minute chromosomes (DM) and homogeneously stained regions (HSR) are cytological manifestations of DNA amplification. Gain of chromosome 19 is a recu...
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