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Article

Insulin secretion and insulin sensitivity are normal in non-diabetic subjects from maternal inheritance diabetes and deafness families.

Diabetic medicine : a journal of the British Diabetic Association - 1 May 2001

Holmes-Walker D J, Ward G M, Boyages S C

Abstract excerpt

BACKGROUND: The pathophysiological mechanism of diabetes mellitus in the presence of the 3243 A-G tRNALEU(UR) mitochondrial DNA mutation is thought to result from deficient insulin secretion. However, few subjects with normal glucose tolerance have been studied to determine the sequence of events resulting in the development of diabetes mellitus. AIM: To determine whether abnormalities of insulin sensitivity,...

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Identifiers

PMID: 11472449
DOI: 10.1046/j.1464-5491.2001.00472.x

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