Article
Clinical and laboratory characteristics in the families with diabetes and a mitochondrial tRNA(LEU(UUR)) gene mutation.
Diabetes research and clinical practice - 1 Aug 1995
Iwanishi M, Obata T, Yamada S, Maegawa H, Tachikawa-Ide R, Ugi S, Hasegawa M, Kojima H, Oguni T, Toudo R
Abstract excerpt
We identified three families having a mutation in the mitochondrial tRNA(LEU(UUR)) gene at bp 3243 in 300 patients with non-insulin dependent diabetes mellitus (NIDDM), who had first degree relatives of patients with NIDDM. We found six individuals with diabetes, one with impaired glucose toleran...
Topics
- Adolescent
- Adult
- Base Sequence
- DNA Primers
- DNA, Mitochondrial
- Diabetes Mellitus, Type 2
- Female
- Humans
- Insulin
- Insulin Resistance
- Insulin Secretion
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pedigree
- RNA, Transfer, Leu