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Clinical and laboratory characteristics in the families with diabetes and a mitochondrial tRNA(LEU(UUR)) gene mutation.

Diabetes research and clinical practice - 1 Aug 1995

Iwanishi M, Obata T, Yamada S, Maegawa H, Tachikawa-Ide R, Ugi S, Hasegawa M, Kojima H, Oguni T, Toudo R

Abstract excerpt

We identified three families having a mutation in the mitochondrial tRNA(LEU(UUR)) gene at bp 3243 in 300 patients with non-insulin dependent diabetes mellitus (NIDDM), who had first degree relatives of patients with NIDDM. We found six individuals with diabetes, one with impaired glucose tolerance (IGT), and five with normal glucose tolerance (NGT) among three families. Insulin secretory response to oral glucose...

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Identifiers

PMID: 8591702
DOI: 10.1016/0168-8227(95)01108-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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