Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.

doi:10.1002/(sici)1097-0215(19981123)78:5<576::aid-ijc8>3.0.co;2-5

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Article

Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.

International journal of cancer - 23 Nov 1998

Imai Y, Inoue T, Ishikawa T

Abstract excerpt

MSH6 has been implicated in repair of single base mispairs and single-base deletion/insertion mutations. Established MSH6-null mice present a frequent occurrence of gastrointestinal tumors without microsatellite instability (MI), suggesting the possibility of the APC gene being a mutational targe...

Topics

Adult
Aged
Aged, 80 and over
Ampulla of Vater
Common Bile Duct Neoplasms
DNA-Binding Proteins
Female
Fungal Proteins
Genes, APC
Humans
Male
Microsatellite Repeats
Middle Aged
Mutation
Saccharomyces cerevisiae Proteins
Stomach Neoplasms
Tumor Suppressor Protein p53

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