Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.

International journal of cancer - 23 Nov 1998

Imai Y, Inoue T, Ishikawa T

Abstract excerpt

MSH6 has been implicated in repair of single base mispairs and single-base deletion/insertion mutations. Established MSH6-null mice present a frequent occurrence of gastrointestinal tumors without microsatellite instability (MI), suggesting the possibility of the APC gene being a mutational target. Because human ampullary carcinomas and gastric cancers manifest frequent missense or I-base deletion mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Microsatellite Repeats

Share to Mutation

Share to Saccharomyces cerevisiae Proteins

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9808525
DOI: 10.1002/(sici)1097-0215(19981123)78:5<576::aid-ijc8>3.0.co;2-5

Genes

MSH6
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.PMID 9808525Read ↗

Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype.Semantic proximity Read ↗

Mutations at coding mononucleotide repeats in gastric cancer with the microsatellite mutator phenotype.Semantic proximity Read ↗

Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer.Semantic proximity Read ↗

Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.Semantic proximity Read ↗

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.Semantic proximity Read ↗

The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.Semantic proximity Read ↗

MSH6 missense mutations are often associated with no or low cancer susceptibility.Semantic proximity Read ↗

Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype.Semantic proximity Read ↗

Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features.Semantic proximity Read ↗

Mutations of the 'minor' mismatch repair gene MSH6 in typical and atypical hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.Semantic proximity Read ↗

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.