Article
Mitochondrial cytochrome oxidase immunolabeling in aged human temporal bones.
Hearing research - 1 Jul 2001
Keithley E M, Harris B, Desai K, Linthicum F, Fischel-Ghodsian N
Abstract excerpt
Presbycusis, an age-related hearing loss, is accompanied by histopathological cochlear changes including variable amounts of degeneration of the auditory receptors, neurons and the stria vascularis. The causes of degeneration are unknown, although acoustic trauma and exposure to ototoxic agents are certainly contributors to the cellular degeneration. Acquired mitochondrial DNA defects are postulated as important...
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