Article
Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELAS.
The Laryngoscope - 1 Aug 2003
Takahashi Katsumasa, Merchant Saumil N, Miyazawa Tetsuo, Yamaguchi Toshikazu, McKenna Michael J, Kouda Hiroko, Iino Yukiko, Someya Tsutomu, Tamagawa Yuya, Takiyama Yoshihisa, Nakano Imaharu, Saito Ken, Boyer Philip, Kitamura Ken
Abstract excerpt
OBJECTIVES/HYPOTHESIS: Although hearing loss is common in MELAS (syndrome of mitochondrial encephalopathy, lactic acidosis and stroke-like episodes), the histopathology of the temporal bone has not been reported. The majority of cases of MELAS are linked to a mitochondrial DNA (mtDNA) mutation at nucleotide 3243. In MELAS, normal mtDNA and mutant mtDNA coexist in a heteroplasmic manner. The purpose of the study...
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